Cell Line Development

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Development of stable high-expression cell line

We develop stable, high-expression cell lines with high productivity.
Using Prestige Biologics' patent, “Bicistronic Expression Vector”, we provide the best cell line to our customers.

Content of
technology

Production of a promoter including the first expression cassette and the second expression cassette together
It was confirmed that the light and heavy chain genes of antibody therapeutics can be highly expressed together with the amplified gene

Bicistronic expression vector for antibody expression

Schematic diagram of technology

(General vector technology): 1. CMV promoter/AI/Light chain, 2. CMV promoter/AI/Heavy chain, 3. GS or DHER/ CMV promoter or SV40 promoter > (Bicistronic vector): CMV promoter/ UTR + Intron/ Light chain/ CMV promoter/ UTR + Intron/ Heavy chain/ IRES/ DHER > Animal cells for antibody expression => Able to highly express the desired antibody by establishing a stable production cell line

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